Sinomenine mitigates collagen-induced arthritis mice by inhibiting angiogenesis

Arthritis in mice induced by a single immunisation with collagen.

OBJECTIVE To determine whether collagen induced arthritis (CIA) in mice can be satisfactorily induced by a single immunisation and whether this model has some advantages compared with conventional CIA, which is induced by two immunisations. METHODS The incidence of arthritis was observed under different immunisation conditions (variation of species of Mycobacterium included in complete Freund...

Attenuation of Collagen-Induced Arthritis in Mice by Salmon Proteoglycan

Rheumatoid arthritis (RA) is a serious autoimmune disease caused by chronic inflammation of connective tissues. The basic principle of RA treatment is aimed to reduce joint inflammation. Our previous studies demonstrated that salmon cartilage proteoglycan (PG) suppresses excess inflammation in different mouse inflammatory diseases. In this study, we investigated the prophylactic effect of PG on...

Inhibition of Collagen-Induced Arthritis in Mice

Type Ii Collagen - Induced Arthritis in Mice

The induction of immunological reactivity to type II collagen, a major component of cartilage, has recently been used to establish an experimental model of arthritis in the rat (1). Trentham and colleagues (1) have shown that the intradermal injection of collagen in Freund's complete or incomplete adjuvant elicits an arthritogenic reaction, specifically with native type II collagen. Arthritis o...

Angiogenesis inhibition suppresses collagen arthritis

Neovascularization is observed in a spectrum of diseases such as solid tumors, diabetic retinopathy, and rheumatoid arthritis. It is also evident in rat collage-induced arthritis (CIA), an animal model with histologic, clinical, and radiographic manifestations resembling rheumatoid arthritis. To evaluate the effects of angioinhibition in CIA, Louvain rats were immunized with type II collagen to...